TRAINING COURSES

INTRODUCTION TO CLINICAL MASS SPECTROMETRY

Developed and delivered for Mass Spectrometry, Applications to the Clinical Laboratory

This two-day high intensity short course is designed to introduce clinical analysts to the theory and practice of hyphenated chromatographic- mass spectrometric analysis for the analysis of human clinical samples. Fundamental chromatographic theory is explained emphasizing how to achieve baseline resolution in the minimum amount of time for both gas and liquid chromatographic separations. It develops the operating principles and critical operating parameters of both single and tandem analyzer mass spectrometers as well as the process for extracting high quality patient results from the raw data.

GAS CHROMATOGRAPHY - MASS SPECTROMETRY

Minnesota Chromatography Forum

This three-day concentrated course covers all the science and technology necessary to perform qualitative and quantitative analysis of unknown samples using GC-MS.  GC sample introduction techniques and column selection are discussed as is preparing the mass spectrometer for analysis, the types of MS data acquisition and the associated parameters.  The concepts of qualitative analysis, including both manual and automated spectra interpretation are also included.  The principles of high specificity, high accuracy, and high precision quantitative analysis and common quantitative methods are discussed.

UPDATED COURSE:  INTRODUCTION TO INTERPRETATION OF MASS SPECTRA

Georgia ACS Section

This two-day intensive problem oriented course identifies the data that is contained in a mass spectrum and how to apply that data to the interpretation of unknown spectra.  Both unit mass and high resolution accurate mass (HRAM)  information is discussed.  The application of isotopic information associated with commonly encountered elements as a stand-alone tool or in conjunction with HRAM data and logical loses assists with calculating potential molecular formulae and structure assignments.

UPDATED COURSE:  MS FRAGMENTATION MECHANISMS

Georgia ACS Section

This two-day intensive problem oriented course focuses on the chemistry underlying the fragmentation of organic molecules either from high energy electron ionization (GC) or softer ionization techniques such as electrospray ionization (ESI) with collisional activation. Both simple and complex (“rearrangement reactions”) fragmentation processes are discussed and reinforced with problem solving illustrating each mechanism.